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Naloxone hydrochloride
CAS No. 357-08-4
Naloxone hydrochloride( N-Allyldihydro-14-hydroxynormorphinone | NIH 7890 )
Catalog No. M14225 CAS No. 357-08-4
Naloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 37 | In Stock |
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| 200MG | 56 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNaloxone hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionNaloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose.
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DescriptionNaloxone hydrochloride is an opioid inverse agonist drug used to counter the effects of opiate overdose.
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In Vitro——
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In VivoNaloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP). Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression.
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SynonymsN-Allyldihydro-14-hydroxynormorphinone | NIH 7890
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number357-08-4
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Formula Weight363.84
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Molecular FormulaC19H21NO4·HCl
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Purity>98% (HPLC)
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SolubilityWater: 73 mg/mL (200.63 mM); DMSO: 73 mg/mL (200.63 mM)
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SMILESC=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Gluten Exorphin C
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.Gluten Exorphin C, isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten, was considered as a δ-opioid receptor-selective ligand.Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten.
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DuP 747 HCl
DuP 747 HCl is a selective kappa agonist with analgesic activity.DuP 747 consists of two conformations.
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Calenduloside E
Calenduloside E exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting glucose transport at the brush border of the small intestine in oral glucose-loaded rats.
